Web20 Oct 2024 · Shivanthy Pathmanathan 1 2 , Zhong Yao 1 3 , Paula Coelho 4 5 , Robert Valla 1 6 , Luka Drecun 1 2 , Caroline Benz 1 7 , Jamie Snider 1 3 , Punit Saraon 1 , Ingrid … Web14 Jan 2024 · Cell division cycle 37 (Cdc37) is known to work as a kinase-specific cochaperone, which selectively regulates the maturation of kinases through protein–protein interaction (PPI) with Hsp90. Directly disrupting the Hsp90-Cdc37 PPI is emerging as an alternative strategy to develop anticancer agents through a specific inhibition manner of …
Anna LYAKISHEVA PhD University of Toronto, Toronto U of T ...
WebShivanthy Jones, MBA •Compliance Officer •Privacy Specialist •Analytical Thinker •Problem Solver •Lifelong Learner. Specializing in compliance, privacy, risk management and audit. WebShivanthy Pathmanathan; Ingrid Grozavu; Anna Lyakisheva; Igor Stagljar; In recent years, the research community has, with comprehensive systems biology approaches and related technologies, gained ... fort hare university email address
Discovery and Optimization of Small Molecules Targeting the …
WebYear. Receptor tyrosine kinases and cancer: oncogenic mechanisms and therapeutic approaches. P Saraon, S Pathmanathan, J Snider, A Lyakisheva, V Wong, I Stagljar. Oncogene 40 (24), 4079-4093. , 2024. 53. 2024. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Web24 Feb 2024 · Punit Saraon, Shivanthy Pathmanathan, … Igor Stagljar. Biochemical and structural basis for differential inhibitor sensitivity of EGFR with distinct exon 19 mutations. 10 November 2024. WebAbstract. Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease, notably cancer. Since their discovery, several … dillards beauty event