Cullin_2 domain-containing protein
WebAbstract. The RING-H2 finger protein Rbx1 is a subunit of the related SCF (S kp1– C dc53/Cul1– F-box protein) and von Hippel-Lindau (VHL) tumor suppressor (elongin BC–Cul2–VHL) E3 ubiquitin ligase complexes, where it functions as a component of Cdc53/Rbx1 and Cul2/Rbx1 modules that activate ubiquitination of target proteins by the … WebJan 15, 2024 · In the CRL complex, the cullin protein serves as an elongated scaffold, recruiting the RING-FINGER PROTEIN RING BOX PROTEIN 1 (RBX1) and E2 to its …
Cullin_2 domain-containing protein
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WebJul 2, 2024 · FNIP repeat domain-containing protein (FNIP protein) is a little-studied atypical leucine-rich repeat domain-containing protein found in social amoebae and mimiviruses. Here, a recently reported mimivirus of lineage C, Megavirus baoshan, was analyzed for FNIP protein genes. WebApr 16, 2024 · The BTB domain, also known as POZ (poxvirus and zinc finger) domain, is a protein-protein interaction motif in eukaryotes [ 12]. All eukaryotes have a large variety of proteins that contain a BTB/POZ domain.
WebThis protein also has a C-terminal domain containing suppressor of cytokine signaling (SOCS) box ubiquitin ligase recruitment motifs found in substrate receptor proteins of the Cullin-RING E3 ubiquitin ligases. We demonstrate specific PCMTD1 binding to the canonical methyltransferase cofactor S -adenosylmethionine (AdoMet). WebDec 12, 2002 · Cullins are a family of structurally related proteins that share a C-terminally located, evolutionarily conserved cullin domain ( 1, 2 ). It is well established that several …
WebCullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are found throughout eukaryotes. Humans express seven cullins (Cul1, 2, 3, … WebCRLs are multisubunit complexes containing a cullin (CUL1-7) as scaffold protein, a RING domain protein Rbx1 or Rbx2, an adaptor protein, and a substrate recognition subunit …
WebNov 10, 2000 · F-box proteins contain a wide range of secondary motifs including zinc fingers, cyclin domains, leucine zippers, ring fingers, tetratricopeptide (TPR) repeats, and proline-rich regions. The diversity of …
WebSkp, Cullin, F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined for 26S proteasomal degradation. [1] Along with the anaphase-promoting complex, [2] SCF has important roles in the ubiquitination of proteins involved in the cell cycle. chisago county real estate for saleWebJun 13, 2012 · Protein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. Proteomes. Protein sets from fully sequenced genomes. Annotation systems. Systems used to automatically annotate proteins with high accuracy: UniRule … graphite basis vectorWebDespite the large number of mammalian F-box proteins, in addition to β-TRCP1/2 and FBW7, only one other mammalian F-box protein has been matched to its downstream substrates, namely, SKP2 (Ang and Harper 2004; Cardozo and Pagano 2004).Interestingly, SKP2 is the product of a proto-oncogene, FBW7 is a tumor suppressor (Pagano and … graphite bassWebThe remaining 38 BTB-domain containing proteins were slightly more abundant in CUL3-∆9 (≥2-fold ... Cullin-Ring Ligases (CRL) are multi-subunit E3 ubiquitin ligases nucleated around a cullin scaffold protein controlling the ubiquitin-mediated proteasomal degradation of a large number of protein substrates. Cullin 3 (CUL3), as all cullin ... chisago county recorder officeWebOct 2, 2024 · To date, at least 70 F-box protein receptors have been identified for CRL1, a handful of VHL domain-containing proteins for CRL2: approximately 180 BTB proteins … graphite bathroom light fixturesWebMay 23, 2016 · Cullin-2 is a member of the Cullin family, and it serves as a scaffold protein for Elongin B and C, Rbx1 and various substrate recognition receptors to form E3 … graphite bathroom scrub mittWebApr 28, 2011 · Cullin proteins are molecular scaffolds that have crucial roles in the post-translational modification of cellular proteins involving ubiquitin. The mammalian cullin … chisago county referendum results