Ctrp family: linking immunity to metabolism
WebJan 17, 2012 · The C1q/ TNF-related protein (CTRP) family is involved in the body's metabolism and immunity (Schäffler and Buechler, 2012). CTRPs play important roles … WebSep 1, 2024 · CTRP1 plays an important role in regulating body energy homeostasis and sensitivity to insulin. Studies on animal models have shown that it lowers the concentration of glucose. Elevated concentrations of CTRP1 …
Ctrp family: linking immunity to metabolism
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WebLinking Immunity to Metabolism FIGURE 1: Structural organization of the CTRP family members. a) Domain structure of a CTRP monomeric protein. b) Homotrimeric CTRP protein structure. CTRP monomeric proteins form homotrimeric or/and heterotrimeric protein structures. c) Higher-order protein structures of CTRP trimers. WebSep 4, 2024 · This family, originally identified by Lodish and coworkers, is a highly conserved family consisting of secreted proteins that were cloned on the basis of an adiponectin homology sequence.1Up to now, 15 members have been identified in CTRP superfamily (CTRP1–CTRP15) (Figure 1).
WebNov 5, 2024 · The C1q/TNF-related protein 1 (CTRP1), a novel adipokine, is a member of the CTRP family and is widely expressed in various human tissues . CTRP1 serves as a key regulator of glucose and lipid metabolism and is associated with atherosclerosis, coronary artery disease, and type 2 diabetes [14–17]. WebCTRP family: linking immunity to metabolism It is well known that infectious and inflammatory diseases such as sepsis and severe inflammatory response syndrome are accompanied by metabolic alterations such as insulin resistance. Conversely, metabolic …
WebNov 23, 2024 · To characterize hepatic metabolism in fasted Ctrp3 KO mice, I further analyzed metabolomic profiles in the liver. ... Schäffler A, Buechler C (2012) CTRP family: linking immunity to metabolism. Trends Endocrinol Metab 23:194–204. Article Google Scholar Seldin MM, Tan SY, Wong GW (2014) Metabolic function of the CTRP family of … WebIt is well known that infectious and inflammatory diseases such as sepsis and severe inflammatory response syndrome are accompanied by metabolic alterations such as insulin resistance. Conversely, metabolic diseases such as visceral obesity and type 2 diabetes are characterized by high levels of proinflammatory cytokines. Metabolism and immunity …
WebLinking Immunity to Metabolism FIGURE 1: Structural organization of the CTRP family members. a) Domain structure of a CTRP monomeric protein. b) Homotrimeric CTRP …
WebTo date, 15 additional CTRP family members have been identified that might also play a role in metabolism and immunity. This review … simplicity moteur vanguard 20cvsimplicity model year identificationWebJul 1, 2016 · CTRP family: linking immunity to metabolism Trends Endocrinol. Metab. TEM (2012) View more references Cited by (38) CTRP1: A novel player in cardiovascular and metabolic diseases 2024, Cytokine Show abstract C1q/TNF-related Protein 1, a Multifunctional Adipokine: An Overview of Current Data 2024, American Journal of the … simplicity model number locationWebApr 1, 2012 · The function and mechanism of CTRP-3 in adipocytes and monocytes are probed and it is shown that it acts as an endogenous antagonist of the toll-like receptor … simplicity mount st mary\u0027sWebFeb 4, 2024 · CTRPs are a group of fifteen proteins with a role similar to that of adiponectin in metabolism (Table 1) [ 7 ]. CTRPs contain four distinct domains, which include a short variable domain, a C-terminal C1q globular domain, a collagenous domain and an N-terminal signal peptide (Fig. 1) [ 7 ]. simplicity mount st marys universityWebMay 17, 2024 · Center for Metabolism and Obesity Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA ... Shareable Link. Use the link below to share a full-text version of this article with your friends and colleagues. ... C1q/TNF-related proteins (CTRP1-15) constitute a conserved group of secreted proteins of the C1q … simplicity mountainWebApr 25, 2024 · Adiponectin belongs to the C1q/TNF-related protein (CTRP) family, which also has 15 additional identified members (CTRP1-15) with shared structural homology. The members of this tightly conserved family are secreted plasma proteins that play diverse roles in metabolism and immunity [ 14 , 15 ]. simplicity mount st mary\\u0027s